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Open Access Research

Abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza A-associated ARDS

Thomas Weig1, Mirjam I Schubert2, Norbert Gruener3, Michael E Dolch1, Lorenz Frey1, Jens Miller1, Thorsten Johnson2 and Michael Irlbeck1*

Author Affiliations

1 Department of Anaesthesiology, Ludwig-Maximilians-University, Munich, 81366, Germany

2 Department of Clinical Radiology, Ludwig-Maximilians-University, Munich, 81366, Germany

3 Department of Medicine II, Ludwig-Maximilians-University, Munich, 81366, Germany

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European Journal of Medical Research 2012, 17:30  doi:10.1186/2047-783X-17-30

Published: 22 December 2012

Abstract

Background

Secondary sclerosing cholangitis is a severe disease of the biliary tract. Over the last decade, several cases of sclerosing cholangitis in critically ill patients (SC-CIP) were reported. Reports in the literature so far are characterized by a wide variety of underlying causes of critical illness, thereby hindering a risk-factor analysis. We report on a homogenous cohort of critically ill patients with influenza A (H1N1) pneumonia and severe acute respiratory distress syndrome (ARDS), of whom a subgroup developed sclerosing cholangitis, allowing for probing of risk factors associated with SC-CIP.

Methods

Twenty-one patients (5 female, 16 male, 46.3 ± 10.8 years) with severe ARDS due to H1N1 pneumonia were retrospectively divided into two groups, characterized by the presence (n = 5) and absence of SC-CIP (n = 16). A large array of clinical data, laboratory parameters, and multi-detector computed tomography-derived measures were compared.

Results

Both patient groups showed severe pulmonary impairment. Severity of disease on admission day and during the first 14 days of treatment showed no difference. The patients developing SC-CIP had a higher body mass index (BMI) (37.4 ± 6.0 kg/m2 vs. 29.3 ± 6.8 kg/m2; P = 0.029) and a higher volume of intraperitoneal fat (8273 ± 3659 cm3 vs. 5131 ± 2268 cm3; P = 0.033) and spent a longer cumulative period in the prone position during the first 14 days (165 ± 117 h vs. 78 ± 61 h; P = 0.038).

Conclusion

Our results suggest that obesity, intraperitoneal fat volume, and a longer cumulative duration spent in the prone position may put patients with ARDS at risk of developing SC-CIP. These results lead us to propose that the prone position should be carefully deployed, particularly in abdominally obese patients, and that frequent checks be made for early hepatic dysfunction.

Keywords:
Intraperitoneal fat; Multi-organ dysfunction syndrome; Obesity; Prone position; Sclerosing cholangitis in critically ill patients