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Open Access Case report

A fatal case of AIDS-defining meningoencephalitis by C. Neoformans, sensitive to antifungal therapy

S Mohammad-Khani1*, B Otremba2, R Klein3, HH Capelle4, F Logemann5, FC Bange6, RE Schmidt1 and M Stoll1

Author Affiliations

1 Medical University of Hannover, Clinic for Immunology and Rheumatology, Germany

2 Haematooncology practice, Oldenburg, Germany

3 Medical University of Hannover, Division of Neuropathology, Germany

4 Medical University of Hannover, Clinic for Neurosurgery, Germany

5 Medical University of Hannover, Clinic for Anaesthesiology and Intensive Care, Germany

6 Medical University of Hannover, Division of Microbiology, Germany

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European Journal of Medical Research 2010, 15:504-506  doi:10.1186/2047-783X-15-11-504

Published: 25 November 2010

Abstract

Cryptococcus neoformans is the most common cause of life threatening meningoencephalitis in HIV-infected patients. Diagnosis is based on tests for cryptoccocal antigen in serum and cerebrospinal fluid, and on culture of the organism. We present a case of AIDS-related cryptococcal meningoencephalitis unresponsive to antifungal combination therapy, despite of evidence of fungal susceptibility in vitro. Significant decreases in cryptococcal antigen titers in serum and cerebrospinal fluid did not correlate with progress in disease and fatal outcome.

Keywords:
Cryptococcal meningitis; HIV; antifungal therapy; cryptoccocal antigen assay